Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.
vanderbilt.edu
Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.
The oxygen-sensitive hypoxia-inducible factor (HIF) pathway plays a central role in the control of erythropoiesis and iron metabolism. The discovery of prolyl hydroxylase domain (PHD) proteins as key regulators of HIF activity has led to the development of inhibitory compounds that are now in phase 3 clinical development for the treatment of ...
Aug 3, 2018
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