Protein, Leucine & mTOR: Balance for Longevity 🧬💪 mTOR is a master growth switch. Leucine-rich protein (and insulin) turns it on—great for muscle, recovery, and metabolic health. Turning it down at times—via fasting, lower protein windows, polyphenols, or exercise-induced AMPK—supports cellular repair, autophagy, and lifespan (seen across multiple model organisms). The playbook isn’t “always on” or “always off.” It’s strategic cycling: • Hit a leucine threshold (~2–3 g) with 30–50 g high-quali
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Protein, Leucine & mTOR: Balance for Longevity 🧬💪 mTOR is a master growth switch. Leucine-rich protein (and insulin) turns it on—great for muscle, recovery, and metabolic health. Turning it down at times—via fasting, lower protein windows, polyphenols, or exercise-induced AMPK—supports cellular repair, autophagy, and lifespan (seen across multiple model organisms). The playbook isn’t “always on” or “always off.” It’s strategic cycling: • Hit a leucine threshold (~2–3 g) with 30–50 g high-quali
80.1K views5 months ago
FacebookHealthy Life Nuggets: Longevity, Brain Health, …
mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation
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mTOR will make you bigger: The mTOR pathway is a central regulator of metabolism with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain. The activation of TORC1 activation is required for myofibrillar muscle protein synthesis and skeletal muscle hypertrophy in humans in response to both physical exercise and ingestion of certain amino acids or amino acid derivatives. Here is a very good lecture by David Sabatini about the regulation
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FacebookEM-SportScience
Dr. Gundry explains why you're probably eating too much protein
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mTOR (mechanistic Target Of Rapamycin) senses nutrients and decides whether your cells should grow or repair. High nutrients → mTOR up → Growth mode Low nutrients → mTOR down → Maintenance mode Here's why it matters: The maintenance state (low mTOR) is associated with slower aging. Animals with reduced mTOR activity tend to live longer and remain healthier. What affects mTOR: Fasting/caloric restriction (lowers it) Protein intake (raises it) Exercise (raises it acutely) Rapamycin (inhibits it) Y
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mTOR (mechanistic Target Of Rapamycin) senses nutrients and decides whether your cells should grow or repair. High nutrients → mTOR up → Growth mode Low nutrients → mTOR down → Maintenance mode Here's why it matters: The maintenance state (low mTOR) is associated with slower aging. Animals with reduced mTOR activity tend to live longer and remain healthier. What affects mTOR: Fasting/caloric restriction (lowers it) Protein intake (raises it) Exercise (raises it acutely) Rapamycin (inhibits it) Y
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TikTokoptispan
Your anabolic switch isn’t getting turned on properly. That switch is called mTOR. It’s your body’s primary sensor for deciding whether to build tissue or break it down. When mTOR detects abundance - amino acids, glucose, ATP - it activates protein synthesis and muscle growth. When it detects scarcity or stress, it flips catabolic and starts breaking tissue down. Everything you do in and out of the gym either turns this switch on or off. Four things activate mTOR. Mechanical tension from lifting
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Your anabolic switch isn’t getting turned on properly. That switch is called mTOR. It’s your body’s primary sensor for deciding whether to build tissue or break it down. When mTOR detects abundance - amino acids, glucose, ATP - it activates protein synthesis and muscle growth. When it detects scarcity or stress, it flips catabolic and starts breaking tissue down. Everything you do in and out of the gym either turns this switch on or off. Four things activate mTOR. Mechanical tension from lifting
113 views1 month ago
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