Early protein clumps begin the first silent changes of Alzheimer disease. The earliest changes in Alzheimer disease begin with small protein clumps forming between and inside brain cells. The two main proteins involved are beta amyloid and tau. Beta amyloid is normally cleared away by the brain, but when this process slows down, the protein begins to collect in small sticky pieces. These pieces join together and form tiny clusters. At first they are so small that they do not disturb brain functi
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Losing your sense of smell may be more than an annoyance—it could be an early sign of Alzheimer’s. Research from the University of Chicago found that people with the APOE e4 gene were 37 percent more likely to experience smell loss by age 65, often years before memory problems appeared. In early Alzheimer’s, immune cells called microglia can mistakenly damage nerve connections between the brain’s smell center and other regions. This disrupts the ability to detect scents and can even lead to comp
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