Estradiol vaginal cream is a medication that treats irritation, dryness and pain during sex caused by menopause.

Sep 25, 2024 · Read on to learn the side effects of using estradiol vaginal cream, including both mild and more serious side effects, and how to manage them.

Apr 22, 2024 · Learn about the side effects of estradiol topical, from common to rare, for consumers and healthcare professionals.

Oct 1, 2025 · To do so may cause unwanted side effects. This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, breast, or vagina. Do not use it on skin areas that …

Oct 20, 2024 · Overview: Vaginal estradiol is available as a cream, insert, or ring that is inserted into the vagina to increase estrogen levels. It is used after menopause to reduce vaginal …

This article describes common and serious side effects of estradiol vaginal cream. If your doctor prescribes this medication, they can discuss possible side effects with you.

In a large study, women who took estrogens (a group of medications that includes estradiol) by mouth with progestins had a higher risk of heart attacks, strokes, blood clots in the lungs or …

Dec 17, 2025 · Estradiol comes in various forms and is primarily used to treat symptoms of menopause. Side effects vary by form and dosage but may include gastrointestinal issues, …

Jun 7, 2025 · Estradiol cream side effects can range from mild to severe, including breast tenderness, nausea, and vaginal discharge changes.

Nov 3, 2023 · Common Estradiol Vaginal Cream side effects may include headache, nausea, vomiting, vaginal irritation, itching, and fluid retention. A few severe allergic reactions can be …