A cruise to the Panama Canal is filled with country-hopping adventures that take you to Mexico's Mayan ruins, white beaches in Cabo San Lucas or Colonial treasures in Colombia.

Take a cruise with Carnival to the iconic Panama Canal and stop in ports like Colon, Cartagena, and Puntarenas. Book your Carnival cruise today!

The most popular time to cruise around Panama is from winter through spring. During these months, Princess offers a range of itineraries that transit the Panama Canal and visit ports …

Embark on an extraordinary journey through the Panama Canal. Explore engineering marvels, lush rainforests, and diverse wildlife. Book your Panama Canal cruise today!

Unique excursions await everyone on our Panama Canal cruises, from breezy aerial trams through the forest canopy to astounding wildlife encounters and guided city walks.

Traverse the Panama Canal on a Viking voyage. Discover vibrant cities and stunning landscapes as you keep watch for wildlife in crystal-clear waters.

Experience the engineering marvel of the Panama Canal with MSC Cruises. Enjoy breathtaking views and luxurious amenities as you navigate through one of the world's iconic waterways.

Enjoy the best of the Panama Canal with a day to explore the locks, kayak the forested fringes of serene Gatun Lake, or admire the fine Spanish colonial architecture of Panama City’s historic …

Get in the Panama Canal spirit on a cruise to Panama Canal. Learn about Panama Canal, the ships that visit there and select your favorite Panama Canal cruise itinerary.