Jan 16, 2025 · PARP inhibitors are a targeted therapy treatment for some forms of cancers that involve changes (mutations) in the BRCA gene. This includes some types of breast, ovarian and prostate …

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. [1] The PARP family comprises …

Apr 3, 2024 · PARP inhibitors are a type of targeted therapy commonly used to treat breast cancer and ovarian cancer, among others. They target PARP, or poly (ADP-ribose) polymerase, which is a …

Apr 14, 2023 · Poly (ADP-ribose) polymerase inhibitors, also called PARP inhibitors, are targeted therapies that are used to treat cancer. PARP is a protein that has a role in cellular growth, …

Dec 29, 2025 · Clinically, PARP inhibitors (PARPi), such as olaparib, niraparib, rucaparib, and talazoparib, exploit synthetic lethality in homologous recombination-deficient tumors and are …

PARP is a protein (enzyme) found in our cells, it stands for p oly- A DP r ibose p olymerase. It helps damaged cells to repair themselves. As a cancer treatment, PARP inhibitors stop the PARP from …

Feb 27, 2025 · Poly (ADP-ribose) polymerase (PARP) is an enzyme that helps repair DNA damage. PARP inhibitors are drugs that try to keep cancer cells from repairing damaged tumor DNA, leading …

PARP (poly ADP-ribose polymerase) are proteins that bind to broken strands of DNA and recruit other proteins to repair damaged DNA. There are multiple pathways (controlled by multiple genes) …

Among DNA repair pathways, the Poly ADP-ribose polymerase (PARP) family of enzymes, particularly PARP-1, plays an important role. PARP-1 is a protein that detects and binds to single-strand breaks …

A substance that blocks an enzyme in cells called PARP. PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, …