Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreas cancer. It's also the most common form of the ...
Aminoacylation of tRNA is the first step of protein synthesis. Here, we report the co‐crystal structure of human tryptophanyl‐tRNA synthetase and tRNA Trp. This enzyme is reported to interact directly ...
a Gold-standard 0.143 FSC resolution calculated with 3DFSC (Tan et al, 2017). The masks for FSC calculation were generated in CryoSPARC using a relative threshold of 0.5. b Gold-standard 0.143 FSC ...
In all living cells, the genetic code defines the relationship between nucleic acid sequences in protein coding genes with the sequences of amino acids needed to accurately produce all the proteins ...
The manuscript of Davidsen and Sullivan describes an improved tRNA-seq protocol to determine aminoacyl-tRNA levels. The improvements include: (i) optimizing the Whitfeld or oxidation reaction to ...
ABSTRACT: Dimers of tRNAs can form through quasi self-complementary anticodon-anticodon interactions, for example at neutral pH in yeast tRNAAsp(GUC) and at pH4.5 inEscherichia coli tRNAGly(GCC) ...
Aminoacyl-tRNA synthetases (aaRSs) catalyze the reaction of amino acids to their cognate transfer RNAs (tRNAs) in protein synthesis. However, these proteins in eukaryotes are an essential part of the ...
Summary illustrating the steps of the charge tRNA-Seq method we used to measure aminoacylation, relative expression and tRNA modification levels. First, the Whitfeld reaction (detailed in Figure ...
While humans have an esthetic liking for symmetry in everything, nature prefers asymmetric, single-handed forms when it comes to amino acids—the building blocks of proteins, and, by extension, all ...
The genetic information stored in DNA is “decoded” to form proteins via the process of translation. This involves the formation of peptide bonds between amino acids bound to transfer RNA (tRNA) ...
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