Bax and Bak are activated by BH3-only proteins and inhibited by prosurvival Bcl-2 proteins via direct interactions. Bax and Bak undergo major conformation changes during transition from inactive ...
Bax, a central death regulator, is required at the decisional stage of apoptosis. We recently identified serine 184 (S184) of Bax as a critical functional switch controlling its proapoptotic activity.
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