SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with estrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic ...

K. O'Reilly et al., "mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt," Cancer Res, 66:1500—8, 2006. (Cited in 95 papers) It's known that rapamycin inhibits ...

“This research uncovers GPR141 as a stimulator of breast tumorigenesis and metastasis, making it a candidate target for breast cancer therapeutics.” Breast cancer morbidity is surging towards the peak ...

"Medical Journeys" is a set of clinical resources reviewed by physicians, meant for the medical team as well as the patients they serve. Each episode of this 12-part journey through a disease state ...

Metastatic breast cancer (mBC) remains an incurable disease, and most patients will experience disease progression during their treatment course. Although endocrine therapy remains the mainstay of ...

Individuals with certain comorbidities, such as obesity and diabetes, are at a higher risk of being severely infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal ...

(A) The Venn diagram showed the distribution of the DEGs between circFKBP8(5S,6) and cFKBP8-regulated genes. (B, C) DEGs involved in the neuroactive ligand-receptor ...