Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation
Bacterial superantigens are among the most lethal of toxins. Superantigens produced by Staphylococcus aureus and Streptococcus pyogenes trigger an excessive cellular immune response that can lead to ...
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), scientists have been conducting extensive studies to ...
Tumour Targeted Superantigen therapy is a novel form of cancer therapy. The principle involves targeting the superantigen with subsequent activation of cytotoxic T cells in tumor tissue. ABR214936 is ...
The key ingredient in the recipe that make staphylococcus and streptococcus infections so dangerous? Superantigen toxins. A new study from The Hebrew University of Jerusalem, twenty years in the ...
Staphylococcal and streptococcal infections affect millions of individuals each year. They are a leading cause of sepsis and account for many cases of pneumonia and post-surgical infections. Despite ...
Researchers from the University of Pittsburgh School of Medicine and Cedars-Sinai believe they have discovered why some covid-19 patients develop severe inflammation. Since March, scientists have ...
Benezech et al. (Nov. 30 issue) 1 describe cases of six children in the pre–Covid-19 era who presented with an acute inflammatory syndrome and increased T-cell receptor (TCR) expression of Vβ21.3. The ...
Bacterial superantigens (bSAgs) bind as folded proteins to both major histocompatibility complex (MHC) class II molecules on the surfaces of antigen–presenting cells and T cell receptor Vβ domains on ...
Host-pathogen interactions were studied in tissue biopsy samples from patients with severe invasive group A streptococcus (GAS) infections. Skin, subcutaneous tissue, and fascia biopsy samples were ...
This is a preview. Log in through your library . Abstract Background. The Centers for Disease Control and Prevention (CDC) and others reported that methicillin-resistant S. aureus (MRSA) are ...
Children with coronavirus disease 2019 (COVID-19) sometimes develop the Multisystem Inflammatory Syndrome in Children (MIS-C), which is associated with high morbidity. The underlying T-cell associated ...
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