Rather than completely blocking all downstream signals, the peptide developed in this study focuses on inhibiting the activation of p38-MAPK. This is enough to downregulate the development of mature ...

In a new study, researchers from Japan reveal that iSN40 suppresses osteoclast differentiation and bone matrix resorption, offering a potential therapeutic approach for osteoporosis by restoring the ...

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts. This ...

Rheumatoid arthritis (RA) is characterized by joint inflammation and progressive joint damage — a major cause of the progressive disability characteristic of RA patients. However, despite the ...

Osteoporosis is a common skeletal disorder characterized by excessive bone loss, leading to increased fragility and an increased risk of fractures. Osteoclasts, the bone-resorbing cells, are widely ...

Researchers at King's College London have discovered that an immune protein best known for protecting the body against infection also plays an ...