The impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world's population. In the United States, influenza infections occur in ...

Background. A single administration of laninamivir octanoate, a long-acting neuraminidase inhibitor, has been proven to be effective in the treatment of influenza but not for post-exposure prophylaxis ...

A study published in PLOS PATHOGENS describes the prevalence and functions of mutations in neuraminidase enzyme of avian H5N1 influenza viruses that are preferentially selected in human H5N1 influenza ...

Avian Diseases, Vol. 54, No. 1, Supplement: Proceedings of the Seventh International Symposium on Avian Influenza (March 2010), pp. 682-685 (4 pages) A competitive enzyme-linked immunosorbent assay (c ...

As 2017 closes out, national influenza activity is increasing. All 10 US regions characterized by the CDC have reported elevated outpatient influenza-like illness, i.e., above the national or regional ...

Figure 1: Genetic and structural relationships between neuraminidases from different influenza viruses. The crystal structures of N1, N4 and N8 were solved by molecular replacement (see Methods and ...

June 23, 2009 —The safety of neuraminidase inhibitors for treatment of novel H1N1 influenza in pregnant and breast-feeding women is summarized in a review published in the June 15 Online First issue ...

Resistance of influenza A to neuraminidase inhibitors (oseltamivir and zanamivir) has been reported, but the prevalence of influenza B resistance is unknown, as is the potential transmissibility of ...

Seemingly from one influenza season to the next, we have lost the use of our leading antiviral influenza drug because of resistance. This winter, the circulating strain of seasonal influenza A virus ...

The rise of influenza strains resistant to current flu treatments has drug developers looking for new leads. Hope could come from a new family of inhibitors that may effectively block the flu virus ...

Can Statins Save Lives During a Flu Pandemic? In a new study, researchers aimed to assess the effectiveness of neuraminidase inhibitors for use in quick containment of influenza by combining data from ...