San Francisco 49ers vs Chicago Bears picks, predictions, odds, win probabilities for NFL Week 17 Sunday Night Football game on Dec. 28. Who will win?

The Bills are 2.5-point home favorites in the latest Eagles vs. Bills odds from DraftKings, while the over/under for total points scored is 44.5. Buffalo's over/under for total team points is 24.5, while Philadelphia's is 20.

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Only two more regular season weeks remain in the NFL, and Sunday's action features a little bit of a shorter slate after the three games on Christmas Day and tw

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Notable odds: The Bears secured a playoff berth via the Lions' loss to the Steelers in Week 16, and they won the NFC North after their overtime win over the Green Bay Packers, who also fell to the Ravens on Saturday night. The Bears also have about a 14% chance at the No. 1 overall seed.

The Seattle Seahawks are in prime position to win the NFC's first seed this season, controlling their own destiny in the last two weeks.

Here's a closer look at the biggest NFL injuries of Week 17 and what current NFL betting lines look like for the weekend