To cause tuberculosis, the bacterium Mycobacterium tuberculosis must obtain nutrients from host cells. This is facilitated at least in part by protein complexes known as transporters. The structure of ...

The mycobacterial ESX-5 secretion system is located in the bacterial inner membrane and consists of six units, which assemble into a symmetrical structure with a pore at the centre. Credit: Isabel ...

Besides their normal role, pump overexpression confers drug resistance. Knowing the structure is a step to disabling the pumps with inhibitors BIRMINGHAM, Ala. – Tuberculosis is the world’s leading ...

A team of scientists, including several from the U.S. Department of Energy's Argonne National Laboratory, have determined the structures of several important tuberculosis enzymes, which could lead to ...

A research team at IDM is leading the development of a sensor that paves the way for the rapid, selective and cost-effective ...

An enzymatic cocktail can kill a variety of mycobacterial species of bacteria, including those that cause tuberculosis. With resistance to chemical antibiotics on the rise, the world needs entirely ...