A Comprehensive Scan of the Mouse Genome To study MEs, the team used deep whole-genome bisulfite sequencing to map DNA methylation in detail. They examined three tissues — brain, kidney, and liver — ...

Using CRISPR-based technologies, the MoDeL team introduces precise genetic modifications in mice, enabling researchers to uncover how mammalian genes maintain health and contribute to disease.

Researchers at the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s Hospital and Baylor College of Medicine recently made an important advance in neurodegenerative disease ...

Scientists at Stanford have found that hyperactivity in the brain’s reticular thalamic nucleus may drive autism-like behaviors. In mouse models, drugs and neuromodulation techniques that suppressed ...

The MEs tended to occur at the beginning of IAP elements, suggesting a region of increased sensitivity. The team also found methylation differences linked to the sex of the mouse, even before sex ...