The Israel-Iran conflict has escalated into its fourth day with mounting casualties, widening attacks, and no sign of diplomatic resolution.

Hundreds of civilians, mostly in Iran, have been killed by dueling airstrikes despite international pleas for de-escalation.

Israel faced retaliation from Iran after launching missiles against Tehran's leadership and energy infrastructure as part of "Operation Rising Lion" this weekend. Iran's military responded with a wave of missile strikes against Israel,

The warning came on the fourth day of the conflict, when the Israeli military claimed it had achieved air superiority over the Iranian capital and could fly over the city without facing major threats.

Although Iran maintains that its nuclear program is for peaceful energy purposes, Israel has long seen it as a threat. Israeli strikes have hit three of Iran’s nuclear facilities — Natanz, Isfahan and Fordow. Little damage appears visible in satellite imagery of Fordow.

President Trump rejected an Israeli plan in recent days to kill Iran's Supreme Leader Ayatollah Ali Khamenei, a senior U.S. official told USA TODAY.

Iran fired a new wave of missile attacks at Israel, killing at least eight people, while Israel warned hundreds of thousands of people in the middle of Tehran to evacuate ahead of new strikes

Stocks are down on Friday, with oil prices surging in the wake of the Israel's military strike on Iran. The S&P 500 slid 48 points, or 0.5%, to 5,998 points in early trading, while the Dow Jones Industrial Average dropped 559 points,