Myeloproliferative neoplasms (MPNs) are myeloid malignancies characterized by the expansion of a multipotent hematopoietic progenitor stem cell [1, 2]. Philadelphia-negative MPNs in the chronic phase ...

Almost all tumours carry one or more cancer driver mutations, which are essential for cell transformation. However, recent advances in cancer genomics have demonstrated that normal human tissues ...

Unique mutations in the H5N1 strain enhance replication in human cells and cause severe disease in mice. The virus has spread from birds to mammals, including dairy cows, and infected humans, with one ...

Gene mutations have consequences both good and bad—from resistance to conditions like diabetes to susceptibility to certain cancers. In order to study these mutations, scientists need to introduce ...

Scientists have revealed parts of the genome that are especially vulnerable to mutations that occur very early on in development. These areas are in the initial portions of genes, where the cell tends ...

A study published in the Proceedings of the National Academy of Sciences by scientists from Israel and Ghana shows that an evolutionarily significant mutation in the human APOL1 gene arises not ...

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