A 2012 Cochrane systematic review (assessed as up to date September 2011, Nelson et al. 2012) investigated non-surgical therapy for anal fissure. A second systematic review of clinical trials ...

Medical therapy is an established first-line approach for the treatment of patients with chronic anal fissure; however, the efficacy of individual agents versus placebo remains to be proven in this ...

Long-term healing of chronic anal fissures is achieved in approximately half of patients who receive botulinum toxin.

An anal fissure is a tear in the lining of the anal canal, or a cut or tear in the anus region, that extends into the anal canal. It can result from constipation, anal sex, infections, and other ...

George S. Speare, M.D. Assistant in surgery, Massachusetts General Hospital. Roy E. Mabrey, M.D. Assistant in surgery, Massachusetts General Hospital. Select the format you want to export the citation ...

Itchy, irritated anal canal? Facing trouble passing stools? Experiencing bloody stools? Suffering from discomfort while sitting for too long? Chances are you must have experienced this symptom at ...