Parkinson's disease (PD) is a movement disorder, the incidence of which increases sharply with age. It is characterized by a massive loss of dopaminergic neurons of the substantia nigra pars compacta ...

DJ-1 (PARK7) is a multifunctional protein central to cellular defence against oxidative stress and proteotoxic insults, with mutations or dysregulation linked to familial and sporadic forms of ...

DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...