Antimicrobial resistance (AMR) is diminishing the effectiveness of existing antibiotics and intensifying the need for discovery pipelines that are both ...
Understanding human gene function in living organisms has long been hampered by fundamental differences between species. Although mice share most protein-coding genes with humans, their regulatory ...
Production of recombinant therapeutic proteins in mammalian cells represents a significant segment of the pharmaceutical market, and therefore striving for increased productivity of these lines ...
AZoLifeSciences on MSN
Replacing large mouse gene regions with human DNA
Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes with entire human sequences has posed significant technical challenges.
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