BMC Pharmacol. 2010;10(8):1-9. We have created an independent dataset in order to evaluate performance without any bias. For this, we downloaded from DrugBank 146 molecules that were reported to be ...

The crystal structure of arguably the most important enzyme in drug metabolism — cytochrome P450 3A4 (CYP3A4) — has been published, and with it comes the surprise discovery that its active site is ...

—A long-overdue study from Japan focused on the docetaxel-associated development of febrile neutropenia in cancer patients and its association with concomitant polypharmacy involving CYP3A4 inhibitors ...

A real-world study of the association between nivolumab exposure and efficacy in patients with metastatic melanoma. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract ...

Cytochromes P450 are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. Suppressed drug metabolism was identified in patients with various inflammatory conditions.

For patients with cancer who choose to use CAM alongside conventional treatment, oncologists must consider the impact of CAM on the narrow therapeutic window of oncolytic drugs, particularly when CAM ...