A BRCA gene mutation ups your risk of these 4 cancers. Here's what to know.

Inheriting a mutation in BRCA1 or BRCA2 puts you at higher risk of breast, prostate, ovarian and pancreatic cancer. Genetic testing and screening can be life-saving.
BIOENGINEER

BRCA Carriers Show Distinct Protein Signatures in Healthy Breast Tissue, Study Finds

A Mayo Clinic-led proteomic study of nearly 5,000 proteins in nonmalignant breast tissue reveals that cancer-free BRCA1/2 ...
BIOENGINEER

ATR Inhibitor Ceralasertib Paired With Olaparib Shows Promise in BRCA-Mutant Breast Cancer

A Phase 1 trial found that combining the ATR inhibitor ceralasertib with the PARP inhibitor olaparib was generally well ...
People

Christina Applegate Had Her Ovaries Removed Because of BRCA1 — Should You Get the Gene Test?

Breast cancer survivor Christina Applegate announced that she had her ovaries and fallopian tubes removed because she has the BRCA1 mutation — should you get tested? In 2008, Christina Applegate was ...
Medical Xpress

Those with the BRCA1 gene mutation may face greater risk for aggressive cancer caused by asbestos exposure

A group of researchers from Nagoya University in Japan used a rat model to show that the BRCA1 mutation, which affects 1 in 500 people, increases the risks of malignant mesothelioma (MM), a cancer ...
Long Island Press

A Wantagh mother’s journey From BRCA1 diagnosis to breast cancer survivor

At 28, Margot Casino took a 23andMe ancestry test for fun. The Wantagh resident was particularly interested in learning more ...
Nature

BRCA1 is an essential regulator of heart function and survival following myocardial infarction

Discover the latest articles and news in related subjects. As BRCA1 has an integral role in promoting DNA damage repair, we hypothesized that BRCA1 regulates cardiomyocyte survival and that loss of ...
Medical Xpress

Research explains the role of the gene BRCA1 in DNA repair

Scientists at the University of Birmingham are a step closer to understanding the role of the gene BRCA1. Changes in this gene are associated with a high risk of developing breast and ovarian cancer.
Science Daily

Novel role of BRCA1 in tumor suppression

Research shows that the breast cancer gene 1 (BRCA1) not only pushes accurate DNA repair to guard against cancer but promotes subsequent activity in tumor suppression. A new study led by The ...
Science Daily

DNA repair protein BRCA1 implicated in cognitive function and dementia

Researchers have shown for the first time that the protein BRCA1 is required for normal learning and memory and is depleted by Alzheimer's disease. BRCA1 is a key protein involved in DNA repair, and ...
Nature

Roles of BRCA1 in centrosome duplication

Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes ...
News Medical

BRCA1 Interactions

The BRCA1 gene is located on the long arm of chromosome 17, at position 17q21. The gene spans around 100 kilobases and codes for a protein containing 1863 amino acids. Mutations or alterations that ...